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Beilstein J. Org. Chem. 2022, 18, 1524–1531, doi:10.3762/bjoc.18.161
Graphical Abstract
Figure 1: Structures of RBV, betulinic acid (1), and ursolic acid (2).
Scheme 1: Synthesis of 1-azido-3-nitrobenzene (c).
Scheme 2: Synthesis of the triazole-substituted triterpene derivatives 7 and 8.
Figure 2: (A) Activity of compound 8 in A549 cells infected with RSV. MTT assay 96 h after treatment. DMSO (0...
Figure 3: Superposition of the top-ranked docking solution of compound 8 (carbon atoms in yellow, in stick re...